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Article

Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity.

PloS one - 1 Jan 2014

Smith Stephanie, Fox Jennifer, Mejia Marco, Ruangpradit Wanvipa, Saberi Alihossein, Kim Sunmi, Choi Yongjun, Oh Sehyun, Wang Yucai, Choi Kyungho, Li Lei, Hendrickson Eric A, Takeda Shunichi, Muller Mark, Myung Kyungjae

Abstract excerpt

BACKGROUND: We have previously used the ATAD5-luciferase high-throughput screening assay to identify genotoxic compounds with potential chemotherapeutic capabilities. The successful identification of known genotoxic agents, including the histone deacetylase inhibitor (HDACi) trichostatin A (TSA), confirmed the specificity of the screen since TSA has been widely studied for its ability to cause apoptosis in cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24466340
DOI: 10.1371/journal.pone.0087203
PMCID: PMC3900704

Genes

ATAD5
ATM
BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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