Article
Heritable and cancer risks of exposures to anticancer drugs: inter-species comparisons of covalent deoxyribonucleic acid-binding agents.
Mutation research - 25 May 1998
Vogel E W, Barbin A, Nivard M J, Stack H F, Waters M D, Lohman P H
Abstract excerpt
In the past years, several methodologies were developed for potency ranking of genotoxic carcinogens and germ cell mutagens. In this paper, we analyzed six sub-classes of covalent deoxyribonucleic acid (DNA) binding antineoplastic drugs comprising a total of 37 chemicals and, in addition, four al...
Topics
- Animals
- Antineoplastic Agents
- Carcinogenicity Tests
- Chromosome Aberrations
- Chromosome Deletion
- Cross-Linking Reagents
- DNA
- Databases, Factual
- Dose-Response Relationship, Drug
- Genes
- Germ Cells
- Humans
- Lethal Dose 50
- Meiosis
- Mutagenicity Tests