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Article

Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2015

Chen Yih-Wen, Harris Robert A, Hatahet Zafer, Chou Kai-ming

Abstract excerpt

Obesity and the metabolic syndrome have evolved to be major health issues throughout the world. Whether loss of genome integrity contributes to this epidemic is an open question. DNA polymerase η (pol η), encoded by the xeroderma pigmentosum (XP-V) gene, plays an essential role in preventing cutaneous cancer caused by UV radiation-induced DNA damage. Herein, we demonstrate that pol η deficiency in mice (pol...

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Identifiers

PMID: 26240351
DOI: 10.1073/pnas.1506954112
PMCID: PMC4547227

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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