Human pluripotent stem cell-based models suggest preadipocyte senescence as a possible cause of metabolic complications of Werner and Bloom Syndromes

Abstract excerpt

Abstract Werner Syndrome (WS) and Bloom Syndrome (BS) are disorders of DNA damage repair caused by biallelic disruption of the WRN or BLM DNA helicases respectively. Both are commonly associated with insulin resistant diabetes, usually accompanied by dyslipidemia and fatty liver, as seen in lipodystrophies. In keeping with this, progressive reduction of subcutaneous adipose tissue is commonly observed. To...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Nuclear Structure and Function
• Share to Pluripotent Stem Cells Research
• Share to Telomeres, Telomerase, and Senescence