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Obesity, DNA Damage, and Development of Obesity-Related Diseases

6 Mar 2019

Abstract excerpt

Obesity has been recognized to increase the risk of such diseases as cardiovascular diseases, diabetes, and cancer. It indicates that obesity can impact genome stability. Oxidative stress and inflammation, commonly occurring in obesity, can induce DNA damage and inhibit DNA repair mechanisms. Accumulation of DNA damage can lead to an enhanced mutation rate and can alter gene expression resulting in disturbances...

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PMID: 30845725
DOI: 10.3390/ijms20051146

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