Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The dual nature of DNA damage response in obesity and bariatric surgery-induced weight loss

10 Sept 2024

Abstract excerpt

This novel study applies targeted functional proteomics to examine tissues and cells obtained from a cohort of individuals with severe obesity who underwent bariatric surgery (BS), using a Reverse-Phase Protein Array (RPPA). In obese individuals, visceral adipose tissue (VAT), but not subcutaneous adipose tissue (SAT), shows activation of DNA damage response (DDR) markers including ATM, ATR, histone H2AX, KAP1,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines, Inflammation, and Metabolic Diseases
Share to Adipose Tissue and Metabolism
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39256343
DOI: 10.1038/s41419-024-06922-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The dual nature of DNA damage response in obesity and bariatric surgery-induced weight lossPMID 39256343Read ↗

Impact of Obesity-Related Endoplasmic Reticulum Stress on Cancer and Associated Molecular TargetsSemantic proximity Read ↗

Integrating the metabolic and molecular circuits in diabetes, obesity and cancer: a comprehensive reviewSemantic proximity Read ↗

Proteome-wide alterations on adipose tissue from obese patients as age-, diabetes- and gender-specific hallmarksSemantic proximity Read ↗

Obesity, DNA Damage, and Development of Obesity-Related DiseasesSemantic proximity Read ↗

Sustained Activation of TNFα-Induced DNA Damage Response in Newly Differentiated AdipocytesSemantic proximity Read ↗

Hyperinsulinemia Is Highly Associated With Markers of Hepatocytic Senescence in Two Independent CohortsSemantic proximity Read ↗

Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2.Semantic proximity Read ↗

Systemic DNA Damage Response and Metabolic Syndrome as a Premalignant StateSemantic proximity Read ↗

Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric SurgerySemantic proximity Read ↗

Transcriptome Profiles of Human Visceral Adipocytes in Obesity and Colorectal Cancer Unravel the Effects of Body Mass Index and Polyunsaturated Fatty Acids on Genes and Biological Processes Related to TumorigenesisSemantic proximity Read ↗

Bariatric surgery can acutely modulate ER-stress and inflammation on subcutaneous adipose tissue in non-diabetic patients with obesitySemantic proximity Read ↗

Effects of obesity‐associated plasma markers on adipose stem cell function and epigenetic regulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.