Article

Selective Inhibition of DNA Polymerase Proofreading: A Metabolic–Fidelity Mechanism Explains Agent Orange–Associated Myelodysplasia

2026-07-15

Abstract excerpt

We performed a focused review to better understand the pathogenesis of Agent Orange (AO)-associated myelodysplastic syndrome (MDS). We first examined the mechanisms underlying conventional (de novo) MDS, a clonal hematopoietic neoplasm that typically develops in later life and integrated these findings with our recent analysis of obesity-associated carcinogenesis. Accordingly, we propose that genomic instability i...

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Literature Corpus work: 28e60b23-8243-5975-9076-de49b857b39f
DOI: 10.20944/preprints202607.1061.v1

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