Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sustained Activation of TNFα-Induced DNA Damage Response in Newly Differentiated Adipocytes

29 Sept 2021

Abstract excerpt

The response to DNA damage is the mechanism that allows the interaction between stress signals, inflammatory secretions, DNA repair, and maintenance of cell and tissue homeostasis. Adipocyte dysfunction is the cellular trigger for various disease states such as insulin resistance, diabetes, and obesity, among many others. Previously, our group demonstrated that adipogenesis per se, from mesenchymal/stromal stem...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines, Inflammation, and Metabolic Diseases
Share to Adipose Tissue and Metabolism
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34638889
DOI: 10.3390/ijms221910548

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sustained Activation of TNFα-Induced DNA Damage Response in Newly Differentiated AdipocytesPMID 34638889Read ↗

The dual nature of DNA damage response in obesity and bariatric surgery-induced weight lossSemantic proximity Read ↗

Transcriptional profiling of interleukin-2-primed human adipose derived mesenchymal stem cells revealed dramatic changes in stem cells response imposed by replicative senescence.Semantic proximity Read ↗

DNA Methylation Modulates Aging Process in AdipocytesSemantic proximity Read ↗

ATGL-catalyzed lipid catabolism promotes DNA double-strand break repairSemantic proximity Read ↗

Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities.Semantic proximity Read ↗

Fat tissue, aging, and cellular senescenceSemantic proximity Read ↗

Aging alters tissue resident mesenchymal stem cell propertiesSemantic proximity Read ↗

The fat cell senescence hypothesisSemantic proximity Read ↗

Obesity, DNA Damage, and Development of Obesity-Related DiseasesSemantic proximity Read ↗

Altered regulation of mesenchymal cell senescence promotes pathological changes associated with diabetic wound healingSemantic proximity Read ↗

HMGA2 expression in white adipose tissue linking cellular senescence with diabetesSemantic proximity Read ↗

The Interplay Between Obesity and Type 2 Diabetes: Common Pathophysiological Mechanisms Contributing to Telomere ShorteningSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.