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Article

Metabolic Regulator IAPP (Amylin) Is Required for BRAF and RAS Oncogene-Induced Senescence.

Molecular cancer research : MCR - 1 May 2021

Garnett Sam, de Bruyns Angeline, Provencher-Tom Veronique, Dutchak Kendall, Shu Ran, Dankort David

Abstract excerpt

Cellular senescence is characterized by a prolonged and predominantly irreversible cell-cycle arrest state, which is linked to loss of tissue function and aging in mammals. Moreover, in response to aberrant oncogenic signals such as those from oncogenic RAS or BRAF, senescence functions as an intrinsic tumor suppressor mechanism restraining tumor progression. In addition to this durable proliferative block,...

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Identifiers

PMID: 33500359
DOI: 10.1158/1541-7786.MCR-20-0879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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