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PGC-1α Modulates Telomere Function and DNA Damage in Protecting against Aging-Related Chronic Diseases

20 Aug 2015

Abstract excerpt

Cellular senescence and organismal aging predispose age-related chronic diseases, such as neurodegenerative, metabolic, and cardiovascular disorders. These diseases emerge coincidently from elevated oxidative/electrophilic stress, inflammation, mitochondrial dysfunction, DNA damage, and telomere dysfunction and shortening. Mechanistic linkages are incompletely understood. Here, we show that ablation of peroxisome...

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PMID: 26299964
DOI: 10.1016/j.celrep.2015.07.047

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