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Article

An Essential Poison: Synthesis and Degradation of Cyclic Di-AMP in Bacillus subtilis.

Journal of bacteriology - 1 Oct 2015

Gundlach Jan, Mehne Felix M P, Herzberg Christina, Kampf Jan, Valerius Oliver, Kaever Volkhard, Stülke Jörg

Abstract excerpt

UNLABELLED: Gram-positive bacteria synthesize the second messenger cyclic di-AMP (c-di-AMP) to control cell wall and potassium homeostasis and to secure the integrity of their DNA. In the firmicutes, c-di-AMP is essential for growth. The model organism Bacillus subtilis encodes three diadenylate cyclases and two potential phosphodiesterases to produce and degrade c-di-AMP, respectively. Among the three cyclases,...

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Identifiers

PMID: 26240071
DOI: 10.1128/JB.00564-15
PMCID: PMC4573722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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