Article

Exploring the evolutionary divergence of cyclic di-nucleotide signaling in diverse mycobacterial species

2025-09-16

Abstract excerpt

<h4>ABSTRACT</h4> Cyclic dinucleotides (CDNs), such as cyclic di-AMP (c-di-AMP) and cyclic di-GMP (c-di-GMP), are key second messengers that regulate fundamental bacterial processes, including cell wall synthesis, biofilm formation, antibiotic resistance, stress response, and virulence. These pathways are particularly relevant in major pathogens like Mycobacterium tuberculosis . Increasing evidence highlights th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cc06f3b1-2d0f-5691-bb29-363fd1b72e33
DOI: 10.1101/2025.09.16.676448

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exploring the evolutionary divergence of cyclic di-nucleotide signaling in diverse mycobacterial speciesDOI 10.1101/2025.09.16.676448Read

Identification of the Components Involved in Cyclic Di-AMP Signaling in Mycoplasma pneumoniaeSemantic proximity Read

Structure and function of diadenylate cyclase DacM from <i>Mycoplasma ovipneumoniae</i>Semantic proximity Read

Replenishing the cyclic-di-AMP pool: regulation of diadenylate cyclase activity in bacteria.Semantic proximity Read

c-di-GMP Turn-Over in Clostridium difficile Is Controlled by a Plethora of Diguanylate Cyclases and PhosphodiesterasesSemantic proximity Read

Bacterial second messenger cyclic di‐AMP in streptococciSemantic proximity Read

Atypical cyclic di-AMP signaling is essential for Porphyromonas gingivalis growth and regulation of cell envelope homeostasis and virulenceSemantic proximity Read

Prevailing concepts of c-di-GMP signaling.Semantic proximity Read

Two DHH Subfamily 1 Proteins in Streptococcus pneumoniae Possess Cyclic Di-AMP Phosphodiesterase Activity and Affect Bacterial Growth and VirulenceSemantic proximity Read

Specialized and shared functions of diguanylate cyclases and phosphodiesterases in <i>Streptomyces</i> developmentSemantic proximity Read

Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase.Semantic proximity Read

The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacySemantic proximity Read

An Essential Poison: Synthesis and Degradation of Cyclic Di-AMP in Bacillus subtilis.Semantic proximity Read