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Article

NKG2A gene variant predicts outcome of immunotherapy in AML and modulates the repertoire and function of NK cells.

Journal for immunotherapy of cancer - 1 Aug 2023

Hussein Brwa Ali, Kristenson Linnea, Pesce Silvia, Wöhr Anne, Tian Yarong, Hallner Alexander, Brune Mats, Hellstrand Kristoffer, Tang Ka-Wei, Bernson Elin, Thorén Fredrik B

Abstract excerpt

BACKGROUND: The natural killer (NK) complex (NKC) harbors multiple genes such as KLRC1 (encoding NKG2A) and KLRK1 (encoding NKG2D) that are central to regulation of NK cell function. We aimed at determining to what extent NKC haplotypes impact on NK cell repertoire and function, and whether such gene variants impact on outcome of IL-2-based immunotherapy in acute myeloid leukemia (AML). METHODS: Genotype status...

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Identifiers

PMID: 37648262
DOI: 10.1136/jitc-2023-007202
PMCID: PMC10471874

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