Article

Integrated Genomic Profiling Reveals Mechanisms of Broad Drug Resistance and Opportunities for Phenotypic Reprogramming in Cancer Cells

2025-09-09

Abstract excerpt

<h4>ABSTRACT</h4> Broad drug resistance is a major barrier to effective cancer therapy, driven by diverse genetic, transcriptional, and metabolic adaptations across tumor types. Here, we developed an integrative computational framework that leverages PRISM drug sensitivity profiles from DepMap, multi-omic datasets, and perturbagen libraries to systematically characterize and identify strategies to reverse broad r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a9100848-6e73-515c-81df-c6ca92152b1f
DOI: 10.1101/2025.09.04.674202

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated Genomic Profiling Reveals Mechanisms of Broad Drug Resistance and Opportunities for Phenotypic Reprogramming in Cancer CellsDOI 10.1101/2025.09.04.674202Read

Multi-omics dissection of tumor microenvironment-mediated drug resistance: mechanisms and therapeutic reprogrammingSemantic proximity Read

Integrative Proteogenomic and Single-Cell Analysis Reveals RTK Switching and Metabolic Reprogramming as Synthetic Lethal Vulnerabilities in FGFR Inhibitor ResistanceSemantic proximity Read

Systematic Construction of Relative Expression Ordering Atlas for Pan-Cancer Drug Resistance PredictionSemantic proximity Read

Interactive webtool for analyzing drug sensitivity and resistance associated with genetic signatures of cancer cell linesSemantic proximity Read

Large-scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell LinesSemantic proximity Read

Metabolic drug survey highlights cancer cell dependencies and vulnerabilities.Semantic proximity Read

Mapping the Pathways of Resistance to Targeted TherapiesSemantic proximity Read

Deciphering resistance mechanisms in cancer: final report of MATCH-R study with a focus on molecular drivers and PDX development.Semantic proximity Read

Integrative Pan-Cancer Genomic and Transcriptomic Analyses of Refractory Metastatic CancerSemantic proximity Read

scDrugAtlas: an integrative single-cell drug response database for dissecting tumor heterogeneity in therapeutic efficacySemantic proximity Read

Integrative pan-cancer genomic and transcriptomic analyses of refractory metastatic cancerSemantic proximity Read

CellMinerCDB for Integrative Cross-Database Genomics and Pharmacogenomics Analyses of Cancer Cell LinesSemantic proximity Read