Article
Mutant frequency in comparison to oxidative DNA damage induced by ochratoxin A in L5178Y tk+/- (3.7.2C) mouse lymphoma cells.
Drug and chemical toxicology - 1 Apr 2014
Ali Rahat, Guo Xiaoqing, Lin Haixia, Khan Qaiser M, Ismail Muhammad, Waheed Usman, Ali Tayyaba, Bhalli Javed A
Abstract excerpt
Ochratoxin A (OTA) is a naturally occurring mycotoxin that contaminates animal feed and human food. OTA is nephrotoxic, hepatotoxic, immunosuppressive and a potent renal carcinogen in rodents. In the present study, we evaluated the genotoxicity of OTA in L5178Y tk(+/-) (3.7.2C) mouse lymphoma cel...
Topics
- 4-Nitroquinoline-1-oxide
- Animals
- Benzo(a)pyrene
- Cell Line, Tumor
- Comet Assay
- DNA Damage
- Dose-Response Relationship, Drug
- Lymphoma
- Mice
- Mutagens
- Mutation
- Ochratoxins
- Oxidation-Reduction