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Article

Anomalous genotoxic responses induced in mouse lymphoma L5178Y cells by potassium bromate.

Toxicology - 12 Jan 2010

Priestley Catherine C, Green Richard M, Fellows Michael D, Doherty Ann T, Hodges Nikolas J, O'Donovan Michael R

Abstract excerpt

Potassium bromate (KBrO3) is a well-established rodent kidney carcinogen and its oxidising activity is considered to be a significant factor in its mechanism of action. Although it has also been shown to be clearly genotoxic in a range of in vivo and in vitro test systems, surprisingly, it is not readily detected in several cell lines using the standard alkaline Comet assay. However, previous results from this...

Topics

8-Hydroxy-2'-Deoxyguanosine
Animals
Bromates
Cell Line, Tumor
Comet Assay
Deoxyguanosine
Histones
Lymphoma
Mice
Micronucleus Tests
Mutagens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Source

Identifiers

PMID: 19853637
DOI: 10.1016/j.tox.2009.10.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-19853637-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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