Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The detection of genotoxic activity and the quantitative and qualitative assessment of the consequences of exposures.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie - 1 Jul 2005

Parry James M, Parry Elizabeth M, Johnson George, Quick Emma, Waters Eileen M

Abstract excerpt

A wide range of assays are now available which enable the effective detection of the mutagenic (the induction of gene and chromosomal changes) and more generally genotoxic (cellular interactions such as DNA lesion formation) activity of individual chemicals and mixtures. However, when genotoxic activity has been detected and human exposure occurs the critical questions relate to the qualitative and quantitative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Damage
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hypoxanthine Phosphoribosyltransferase

Share to Lymphocytes

Share to Micronucleus Tests

Share to Mutagens

Share to Risk Assessment

Source

Identifiers

PMID: 16092728
DOI: 10.1016/j.etp.2005.05.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The detection of genotoxic activity and the quantitative and qualitative assessment of the consequences of exposures.PMID 16092728Read ↗

Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity.Semantic proximity Read ↗

Genotoxicology and risk assessment in the era of the human genome project.Semantic proximity Read ↗

Does the 2-test in vitro genotoxicity battery of Ames plus in vitro micronucleus tests detect relevant substances that induce gene mutations in vivo?Semantic proximity Read ↗

Combined assessment of transgenic rodent gene mutation and micronuclei formation by benzo[a]pyrene, N-ethyl-N-nitrosourea, 2,4-diaminotoluene and ethyl carbamate.Semantic proximity Read ↗

Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro.Semantic proximity Read ↗

Further evidence for the rodent bone marrow micronucleus assay acting as a sensitive predictor of the possible germ cell mutagenicity of chemicals.Semantic proximity Read ↗

Tissue-specific in vivo genetic toxicity of nine polycyclic aromatic hydrocarbons assessed using the Muta™Mouse transgenic rodent assay.Semantic proximity Read ↗

Mode of action-based risk assessment of genotoxic carcinogensSemantic proximity Read ↗

Molecular epidemiology of human cancer: biomarkers of genotoxic exposure and susceptibility.Semantic proximity Read ↗

DNA adducts: biological markers of exposure and potential applications to risk assessment.Semantic proximity Read ↗

Integration of liver and blood micronucleus and Pig-a gene mutation endpoints into rat 28-day repeat-treatment studies: Proof-of-principle with diethylnitrosamine.Semantic proximity Read ↗

Molecular dosimetry of chemical mutagens. Relationship between DNA adduct formation and genetic changes analyzed at the molecular level.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.