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Article

Genetic evidence for contribution of human dispersal to the genetic diversity of EBA-175 in Plasmodium falciparum.

Malaria journal - 1 Aug 2015

Yasukochi Yoshiki, Naka Izumi, Patarapotikul Jintana, Hananantachai Hathairad, Ohashi Jun

Abstract excerpt

BACKGROUND: The 175-kDa erythrocyte binding antigen (EBA-175) of Plasmodium falciparum plays a crucial role in merozoite invasion into human erythrocytes. EBA-175 is believed to have been under diversifying selection; however, there have been no studies investigating the effect of dispersal of humans out of Africa on the genetic variation of EBA-175 in P. falciparum. METHODS: The PCR-direct sequencing was...

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Identifiers

PMID: 26231699
DOI: 10.1186/s12936-015-0820-2
PMCID: PMC4522064

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Source receipt: pubmed, retrieved 7 Sept 2026.

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