Article
Genetic polymorphism and natural selection of the erythrocyte binding antigen 175 region II in Plasmodium falciparum populations from Myanmar and Vietnam.
Scientific reports - 16 Nov 2023
Võ Tuấn Cường, Lê Hương Giang, Kang Jung-Mi, Naw Haung, Yoo Won Gi, Myint Moe Kyaw, Quang Huynh Hong, Na Byoung-Kuk
Abstract excerpt
Plasmodium falciparum erythrocyte binding antigen 175 (PfEBA-175) plays essential role in erythrocyte invasion by the parasite and is a leading vaccine candidate. However, its genetic diversity in global isolates is a concern in developing an universal vaccine incorporating this protein. This study aimed to investigate genetic polymorphisms and natural selection of pfeba-175 region II (RII) in Myanmar and Vietnam...
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