Article
Erythrocyte-binding antigens of Plasmodium falciparum are targets of human inhibitory antibodies and function to evade naturally acquired immunity.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2013
Persson Kristina E M, Fowkes Freya J I, McCallum Fiona J, Gicheru Nimmo, Reiling Linda, Richards Jack S, Wilson Danny W, Lopaticki Sash, Cowman Alan F, Marsh Kevin, Beeson James G
Abstract excerpt
Abs that inhibit Plasmodium falciparum invasion of erythrocytes form an important component of human immunity against malaria, but key target Ags are largely unknown. Phenotypic variation by P. falciparum mediates the evasion of inhibitory Abs, contributing to the capacity of P. falciparum to cause repeat and chronic infections. However, Ags involved in mediating immune evasion have not been defined, and studies...
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