Article
Allelic dimorphism of the erythrocyte binding antigen-175 (eba-175) gene of Plasmodium falciparum and severe malaria: Significant association of the C-segment with fatal outcome in Ghanaian children.
Malaria journal - 12 May 2004
Cramer Jakob P, Mockenhaupt Frank P, Möhl Ingo, Dittrich Sabine, Dietz Ekkehardt, Otchwemah Rowland N, Ehrhardt Stephan, Bienzle Ulrich, Jelinek Tomas
Abstract excerpt
BACKGROUND: The erythrocyte binding antigen-175 (EBA-175) on Plasmodium falciparum merozoites mediates sialic acid dependent binding to glycophorin A on host erythrocytes and, therefore, plays a crucial role in cell invasion. Dimorphic allele segments have been found in its encoding gene with a 342 bp segment present in FCR-3 strains (F-segment) and a 423 bp segment in CAMP strains (C-segment). Possible...
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