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Article

Evidence for Diversifying Selection on Erythrocyte-Binding Antigens of <i>Plasmodium falciparum</i> and <i>P. vivax</i>

1 Apr 2003

Abstract excerpt

Malaria parasite antigens involved in erythrocyte invasion are primary vaccine candidates. The erythrocyte-binding antigen 175K (EBA-175) of Plasmodium falciparum binds to glycophorin A on the human erythrocyte surface via an N-terminal cysteine-rich region (termed region II) and is a target of antibody responses. A survey of polymorphism in a malaria-endemic population shows that nucleotide alleles in eba-175...

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PMID: 12702678
DOI: 10.1093/genetics/163.4.1327

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