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Article

High-content phenotypic screening and triaging strategy to identify small molecules driving oligodendrocyte progenitor cell differentiation.

Journal of biomolecular screening - 1 Mar 2015

Peppard Jane V, Rugg Catherine A, Smicker Matthew A, Powers Elaine, Harnish Erica, Prisco Joy, Cirovic Dragan, Wright Paul S, August Paul R, Chandross Karen J

Abstract excerpt

Multiple Sclerosis is a demyelinating disease of the CNS and the primary cause of neurological disability in young adults. Loss of myelinating oligodendrocytes leads to neuronal dysfunction and death and is an important contributing factor to this disease. Endogenous oligodendrocyte precursor cells (OPCs), which on differentiation are responsible for replacing myelin, are present in the adult CNS. As such,...

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PMID: 25394729
DOI: 10.1177/1087057114559490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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