Article
Neuritic outgrowth associated with astroglial phenotypic changes induced by antisense glial fibrillary acidic protein (GFAP) mRNA in injured neuron-astrocyte cocultures.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jun 1997
Lefrançois T, Fages C, Peschanski M, Tardy M
Abstract excerpt
In the adult CNS, axons fail to regenerate after injury. Among the cell interactions that lead to this failure are those developed with astrocytes. In an effort to elucidate the mechanisms underlying these negative interactions, we have used astrocytes treated with antisense glial fibrillary acid...
Topics
- Animals
- Animals, Newborn
- Astrocytes
- Cell Culture Techniques
- Cells, Cultured
- Fluorescent Antibody Technique
- GAP-43 Protein
- Gene Expression
- Glial Fibrillary Acidic Protein
- Gliosis
- Laminin