Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic Screening of Small-Molecule Inhibitors: Implications for Therapeutic Discovery and Drug Target Development in Traumatic Brain Injury.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016

Al-Ali Hassan, Lemmon Vance P, Bixby John L

Abstract excerpt

The inability of central nervous system (CNS) neurons to regenerate damaged axons and dendrites following traumatic brain injury (TBI) creates a substantial obstacle for functional recovery. Apoptotic cell death, deposition of scar tissue, and growth-repressive molecules produced by glia further complicate the problem and make it challenging for re-growing axons to extend across injury sites. To date, there are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axons
Share to Brain Injuries, Traumatic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Culture Techniques

Share to Drug Discovery

Share to Drug Evaluation, Preclinical

Share to High-Throughput Screening Assays

Share to Phosphotransferases

Share to Small Molecule Libraries

Source

Identifiers

PMID: 27604745
DOI: 10.1007/978-1-4939-3816-2_37

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic Screening of Small-Molecule Inhibitors: Implications for Therapeutic Discovery and Drug Target Development in Traumatic Brain Injury.PMID 27604745Read ↗

Phenotypic screening with primary neurons to identify drug targets for regeneration and degeneration.Semantic proximity Read ↗

Phenotypic assays to identify agents that induce reactive gliosis: a counter-screen to prioritize compounds for preclinical animal studies.Semantic proximity Read ↗

A 3D Tissue Model of Traumatic Brain Injury with Excitotoxicity That Is Inhibited by Chronic Exposure to Gabapentinoids.Semantic proximity Read ↗

Phenotypic approaches for CNS drugs.Semantic proximity Read ↗

Phenotypic screening strategies for neurodegenerative diseases: a pathway to discover novel drug candidates and potential disease targets or mechanisms.Semantic proximity Read ↗

High-content phenotypic screening and triaging strategy to identify small molecules driving oligodendrocyte progenitor cell differentiation.Semantic proximity Read ↗

High Content Screening of Mammalian Primary Cortical Neurons.Semantic proximity Read ↗

Neuronal phenotypic alterations and the therapeutic potential of Anxa2 in traumatic brain injury recovery.Semantic proximity Read ↗

Phenotypic screens targeting neurodegenerative diseases.Semantic proximity Read ↗

Planning and Analysis of Axon Degeneration Screening Experiments.Semantic proximity Read ↗

High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress.Semantic proximity Read ↗

Inhibition of microglia activation as a phenotypic assay in early drug discovery.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.