Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fibrinogen deficiency is compatible with the development of atherosclerosis in mice.

The Journal of clinical investigation - 1 Mar 1998

Xiao Q, Danton M J, Witte D P, Kowala M C, Valentine M T, Degen J L

Abstract excerpt

A critical role of the coagulation system in the development of atherosclerosis has been frequently postulated based on a variety of indirect observations, including the expression of procoagulants and fibrinolytic factors within atherosclerotic vessels, the presence of substantial amounts of fib...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mice
Share to Alleles
Share to Apolipoproteins E

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arteriosclerosis

Share to Immunohistochemistry

Share to Mice, Inbred C57BL

Share to Mice, Mutant Strains

Share to Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 9486990
DOI: 10.1172/JCI1461
PMCID: PMC508671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9486990-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fibrinogen deficiency is compatible with the development of atherosclerosis in mice.PMID 9486990Read ↗

Atherosclerosis progression in LDL receptor-deficient and apolipoprotein E-deficient mice is independent of genetic alterations in plasminogen activator inhibitor-1.Semantic proximity Read ↗

Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis.Semantic proximity Read ↗

Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense.Semantic proximity Read ↗

Effects of hyperfibrinogenemia on vasculature of C57BL/6 mice with and without atherogenic diet.Semantic proximity Read ↗

A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice.Semantic proximity Read ↗

Deficiency of tissue factor pathway inhibitor promotes atherosclerosis and thrombosis in mice.Semantic proximity Read ↗

Novel insights into the development of atherosclerosis in hemophilia A mouse models.Semantic proximity Read ↗

Genetic and pharmacological modifications of thrombin formation in apolipoprotein e-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner.Semantic proximity Read ↗

Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif.Semantic proximity Read ↗

Atherosclerotic lesions in mouse and man: is it the same disease?Semantic proximity Read ↗

Remodeling of the vessel wall after copper-induced injury is highly attenuated in mice with a total deficiency of plasminogen activator inhibitor-1.Semantic proximity Read ↗

Detection of Intraplaque Hemorrhage in Mouse Atherosclerotic Lesions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.