Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain

17 Oct 2008

Abstract excerpt

Mice carrying a conditional prothrombin knockout allele (fII(lox)) were established to develop an experimental setting for exploring the importance of thrombin in the maintenance of vascular integrity, the inflammatory response, and disease processes in adult animals. In the absence of Cre-mediated recombination, homozygous fII(lox/lox) mice or compound heterozygous mice carrying one fII(lox) allele and one...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Coagulation and Thrombosis Mechanisms
Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
Share to Hemophilia Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18927430
DOI: 10.1182/blood-2008-07-169003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brainPMID 18927430Read ↗

Prothrombin deficiency results in embryonic and neonatal lethality in mice.Semantic proximity Read ↗

Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice.Semantic proximity Read ↗

Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish.Semantic proximity Read ↗

Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice.Semantic proximity Read ↗

Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation.Semantic proximity Read ↗

Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosisSemantic proximity Read ↗

Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosisSemantic proximity Read ↗

Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafishSemantic proximity Read ↗

Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense.Semantic proximity Read ↗

Acute and severe coagulopathy in adult mice following silencing of hepatic antithrombin and protein C production.Semantic proximity Read ↗

Gene targeting in hemostasis. factor XI.Semantic proximity Read ↗

Thrombin-activatable fibrinolysis inhibitor (TAFI) deficiency is compatible with murine life.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.