Article
Hypofibrinogenemia with preserved hemostasis and protection from thrombosis in mice with an Fga truncation mutation.
Blood - 3 Mar 2022
Hur Woosuk S, Paul David S, Bouck Emma G, Negrón Oscar A, Mwiza Jean-Marie, Poole Lauren G, Cline-Fedewa Holly M, Clark Emily G, Juang Lih Jiin, Leung Jerry, Kastrup Christian J, Ugarova Tatiana P, Wolberg Alisa S, Luyendyk James P, Bergmeier Wolfgang, Flick Matthew J
Abstract excerpt
Genetic variants within the fibrinogen Aα chain encoding the αC-region commonly result in hypodysfibrinogenemia in patients. However, the (patho)physiological consequences and underlying mechanisms of such mutations remain undefined. Here, we generated Fga270 mice carrying a premature termination codon within the Fga gene at residue 271. The Fga270 mutation was compatible with Mendelian inheritance for offspring...
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