Article
Development of pulmonary fibrosis in fibrinogen-deficient mice.
Annals of the New York Academy of Sciences - 1 Jan 2001
Wilberding J A, Ploplis V A, McLennan L, Liang Z, Cornelissen I, Feldman M, Deford M E, Rosen E D, Castellino F J
Abstract excerpt
Bleomycin is an antineoplastic drug commonly used for the treatment of many carcinomas and lymphomas. Its toxic side effect on lung tissue is a major limitation to its use, with approximately 3-5% of patients affected. Although the number of affected patients is small, the damage incurred by bleomycin in these patients is often irreversible and, at times, fatal. A number of therapies have been shown to be...
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