Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice.

doi:10.1101/gad.9.16.2020

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Article

Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice.

Genes & development - 15 Aug 1995

Suh T T, Holmbäck K, Jensen N J, Daugherty C C, Small K, Simon D I, Potter S, Degen J L

Abstract excerpt

To explore the role of the key coagulation factor, fibrinogen, in development, hemostasis, wound repair, and disease pathogenesis, we disrupted the fibrinogen A alpha chain gene in mice. Homozygous, A alpha chain-deficient (A alpha-/-) mice are born normal in appearance, and there is no evidence...

Topics

Afibrinogenemia
Aging
Alleles
Animals
Animals, Newborn
Base Sequence
Blood Cell Count
DNA Primers
Exons
Female
Fibrinogen
Hematocrit
Hemorrhage
Male
Mice
Mice, Transgenic
Molecular Sequence Data
Mutation

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