Article
Bleomycin-induced pulmonary fibrosis in fibrinogen-null mice.
The Journal of clinical investigation - 1 Dec 2000
Hattori N, Degen J L, Sisson T H, Liu H, Moore B B, Pandrangi R G, Simon R H, Drew A F
Abstract excerpt
Mice deleted for the plasminogen activator inhibitor-1 (PAI-1) gene are relatively protected from developing pulmonary fibrosis induced by bleomycin. We hypothesized that PAI-1 deficiency reduces fibrosis by promoting plasminogen activation and accelerating the clearance of fibrin matrices that accumulate within the damaged lung. In support of this hypothesis, we found that the lungs of PAI-1(-/-) mice...
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