Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interleukin-35 administration counteracts established murine type 1 diabetes--possible involvement of regulatory T cells.

Scientific reports - 30 Jul 2015

Singh Kailash, Kadesjö Erik, Lindroos Julia, Hjort Marcus, Lundberg Marcus, Espes Daniel, Carlsson Per-Ola, Sandler Stellan, Thorvaldson Lina

Abstract excerpt

The anti-inflammatory cytokine IL-35 is produced by regulatory T (Treg) cells to suppress autoimmune and inflammatory responses. The role of IL-35 in type 1 diabetes (T1D) remains to be answered. To elucidate this, we investigated the kinetics of Treg cell response in the multiple low dose streptozotocin induced (MLDSTZ) T1D model and measured the levels of IL-35 in human T1D patients. We found that Treg cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Experimental
Share to Hyperglycemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred NOD

Share to Minor Histocompatibility Antigens

Share to Receptors, Cytokine

Share to Streptozocin

Share to T-Lymphocytes, Helper-Inducer

Share to Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 26224624
DOI: 10.1038/srep12633
PMCID: PMC4519737

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interleukin-35 administration counteracts established murine type 1 diabetes--possible involvement of regulatory T cells.PMID 26224624Read ↗

Interleukin-35: A key player in chronic inflammatory Type 1 and autoimmune diabetesSemantic proximity Read ↗

Interleukin 35: A Key Mediator of Suppression and the Propagation of Infectious ToleranceSemantic proximity Read ↗

Interleukin-35 regulates the balance of Th17 and Treg responses during the pathogenesis of connective tissue diseases.Semantic proximity Read ↗

IL-35 recombinant protein reverses inflammatory bowel disease and psoriasis through regulation of inflammatory cytokines and immune cells.Semantic proximity Read ↗

Interleukin-35 Enhances Regulatory T Cell Function by Potentially Suppressing Their Transdifferentiation into a T Helper 17-Like Phenotype in Kawasaki Disease.Semantic proximity Read ↗

T-Regulatory Cell Subsets in Children with Type 1 Diabetes Mellitus: Relation to Control of the Disease.Semantic proximity Read ↗

Extension of the CD4⁺Foxp3⁺CD25(-/low) regulatory T-cell subpopulation in type 1 diabetes mellitus.Semantic proximity Read ↗

IL-35 and Autoimmunity: a Comprehensive PerspectiveSemantic proximity Read ↗

Expansion of Functional Regulatory T Cells Using Soluble RAGE Prevents Type 1 DiabetesSemantic proximity Read ↗

IL-35 Stabilizes Treg Phenotype to Protect Cardiac Allografts in Mice.Semantic proximity Read ↗

IL-35 inhibits acute graft-versus-host disease in a mouse modelSemantic proximity Read ↗

Hematopoietic Stem Cells in Type 1 Diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.