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Article

IL-35 Stabilizes Treg Phenotype to Protect Cardiac Allografts in Mice.

Transplantation - 1 Jan 2024

Huang Ai, Liu Kewei, Yin Ziyi, Liu Jie, Wei Hongyan, Xing Shijie, Qu Yue, Huang Lei, Li Liancheng, Li Chang, Zhang Lei, Li Xiaoshi, Zheng Cunni, Liu Quan, Jiang Ke

Abstract excerpt

BACKGROUND: Interleukin-35 (IL-35), secreted by regulatory T cells (Treg) and B cells, is immunosuppressive under both physiological and pathological conditions. However, the role of IL-35 in all responses has yet to be investigated. Here, we demonstrate that IL-35 protects allografts by stabilizing the Treg phenotype and suppressing CD8 + T-cell activation in a mouse heart transplantation model. METHODS: The...

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Identifiers

PMID: 37464473
DOI: 10.1097/TP.0000000000004707
PMCID: PMC10718222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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