Article
T-Regulatory Cell Subsets in Children with Type 1 Diabetes Mellitus: Relation to Control of the Disease.
Endocrine, metabolic & immune disorders drug targets - 1 Jan 2017
Ghonaim Mabrouk M, El-Edel Rawhia H, Kamal Eldein Samar M, Abo El Fotoh Wafaa Moustafa M, Salman Samar S
Abstract excerpt
BACKGROUND: Type 1 diabetes mellitus is described as a chronic metabolic disorder characterized by aggressive immune β-cell destruction. There are a number of varied immune mechanisms for sustaining self-tolerance in opposition to the autoimmune disorders. A recessive tolerance is accomplished by thymic gland via a negative assortment of different clones, while a dominant tolerance is accomplished by the...
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