Article
Extension of the CD4⁺Foxp3⁺CD25(-/low) regulatory T-cell subpopulation in type 1 diabetes mellitus.
Autoimmunity - 1 Jan 2015
Zóka András, Barna Gábor, Somogyi Anikó, Műzes Györgyi, Oláh Ágnes, Al-Aissa Zahra, Hadarits Orsolya, Kiss Katalin, Firneisz Gábor
Abstract excerpt
Regulatory T-cells (Treg) have a crucial role in limiting physiologic autoreactivity. Foxp3 is a master regulator transcription factor of Treg differentiation and active Treg cells express high levels of IL-2 receptor α-chain (CD25). The aim of our study was to assess the key markers of Treg cell function in type 1 diabetic (T1DM) and control subjects by flow cytometry. The proportion of CD25(-/low) cells among...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
