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Article

Interleukin-35 regulates the balance of Th17 and Treg responses during the pathogenesis of connective tissue diseases.

International journal of rheumatic diseases - 1 Jan 2021

Wang Di, Lei Ling

Abstract excerpt

Interleukin (IL)-35 belongs to the IL-12 cytokine family and is a heterodimer of the p35 and Epstein-Barr virus-induced gene 3 (EBI3) subunits. Functionally, IL-35 can promote the proliferation and activation of regulatory T cells (Tregs) and suppress the function of T helper 17 (Th17) cells and other inflammatory cells to inhibit immune responses. In recent years, an abnormal IL-35 expression causing a Th17/Treg...

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PMID: 32918357
DOI: 10.1111/1756-185X.13962

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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