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Article

Voluntary exercise attenuates LPS-induced reductions in neurogenesis and increases microglia expression of a proneurogenic phenotype in aged mice.

Journal of neuroinflammation - 30 Jul 2015

Littlefield Alyssa M, Setti Sharay E, Priester Carolina, Kohman Rachel A

Abstract excerpt

BACKGROUND: Microglia can acquire various phenotypes of activation that mediate their inflammatory and neuroprotective effects. Aging causes microglia to become partially activated towards an inflammatory phenotype. As a result, aged animals display a prolonged neuroinflammatory response following an immune challenge. Currently unknown is whether this persistent neuroinflammation leads to greater reductions in...

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Identifiers

PMID: 26224094
DOI: 10.1186/s12974-015-0362-0
PMCID: PMC4518639

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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