Article

Repeated LPS induces training and tolerance of microglial responses across brain regions

2024-04-12

Abstract excerpt

<h4>Background</h4> Neuroinflammation is involved in the pathogenesis of almost every central nervous system disorder. As the brain’s innate immune cells, microglia fine tune their activity to a dynamic brain environment. Previous studies have shown that repeated bouts of peripheral inflammation can trigger long-term changes in microglial gene expression and function, a form of innate immune memory. <h4>Methods a...

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Literature Corpus work: 33baa84c-c76f-5d92-8e41-ef5180887626
DOI: 10.1101/2024.04.08.588502

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