Article
Four-and-a-half LIM domain protein 2 (FHL2) deficiency protects mice from diet-induced obesity and high FHL2 expression marks human obesity.
Metabolism: clinical and experimental - 1 Aug 2021
Clemente-Olivo Maria P, Habibe Jayron J, Vos Mariska, Ottenhoff Roelof, Jongejan Aldo, Herrema Hilde, Zelcer Noam, Kooijman Sander, Rensen Patrick C N, van Raalte Daniël H, Nieuwdorp Max, Eringa Etto C, de Vries Carlie J
Abstract excerpt
OBJECTIVE: Four-and-a-Half-LIM-domain-protein 2 (FHL2) modulates multiple signal transduction pathways but has not been implicated in obesity or energy metabolism. In humans, methylation and expression of the FHL2 gene increases with age, and high FHL2 expression is associated with increased body weight in humans and mice. This led us to hypothesize that FHL2 is a determinant of diet-induced obesity. METHODS:...
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