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Article

Foxa2 Programs Th2 Cell-Mediated Innate Immunity in the Developing Lung

5 May 2010

Abstract excerpt

After birth, the respiratory tract adapts to recurrent exposures to pathogens, allergens, and toxicants by inducing the complex innate and acquired immune systems required for pulmonary homeostasis. In this study, we show that Foxa2, expressed selectively in the respiratory epithelium, plays a critical role in regulating genetic programs influencing Th2 cell-mediated pulmonary inflammation. Deletion of the Foxa2...

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PMID: 20483781
DOI: 10.4049/jimmunol.1000223

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