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Article

FoxO1 is a critical regulator of M2‐like macrophage activation in allergic asthma

5 Oct 2018

Abstract excerpt

BACKGROUND: The pathogenesis of asthma and airway obstruction is the result of an abnormal response to different environmental exposures. The scientific premise of our study was based on the finding that FoxO1 expression is increased in lung macrophages of mice after allergen exposure and human asthmatic patients. Macrophages are capable of switching from one functional phenotype to another, and it is important...

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PMID: 30288751
DOI: 10.1111/all.13626

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