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Article

Alpha-1 Antitrypsin Mitigates the Inhibition of Airway Epithelial Cell Repair by Neutrophil Elastase.

American journal of respiratory cell and molecular biology - 1 Mar 2016

Garratt Luke W, Sutanto Erika N, Ling Kak-Ming, Looi Kevin, Iosifidis Thomas, Martinovich Kelly M, Shaw Nicole C, Buckley Alysia G, Kicic-Starcevich Elizabeth, Lannigan Francis J, Knight Darryl A, Stick Stephen M, Kicic Anthony

Abstract excerpt

Neutrophil elastase (NE) activity is associated with many destructive lung diseases and is a predictor for structural lung damage in early cystic fibrosis (CF), which suggests normal maintenance of airway epithelium is prevented by uninhibited NE. However, limited data exist on how the NE activity in airways of very young children with CF affects function of the epithelia. The aim of this study was to determine...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26221769
DOI: 10.1165/rcmb.2015-0074OC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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