Article
Neutrophil elastase mediates innate host protection against Pseudomonas aeruginosa.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2008
Hirche Tim O, Benabid Rym, Deslee Gaetan, Gangloff Sophie, Achilefu Samuel, Guenounou Moncef, Lebargy François, Hancock Robert E, Belaaouaj Azzaq
Abstract excerpt
According to the widely accepted view, neutrophil elastase (NE), a neutrophil-specific serine protease, is a major contributor to Pseudomonas aeruginosa infection-associated host tissue inflammation and damage, which in severe cases can lead to death. Herein, we provide for the first time compelling evidence that the host rather employs NE to protect itself against P. aeruginosa infection. Using a clinically...
Topics
- Animals
- Bacterial Outer Membrane Proteins
- Disease Models, Animal
- Genetic Predisposition to Disease
- Immunity, Innate
- Leukocyte Elastase
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mutation
- Pneumonia, Bacterial
- Pseudomonas Infections
- Pseudomonas aeruginosa