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Article

Inflammatory lung secretions inhibit dendritic cell maturation and function via neutrophil elastase.

American journal of respiratory and critical care medicine - 1 Dec 2006

Roghanian Ali, Drost Ellen M, MacNee William, Howie Sarah E M, Sallenave Jean-Michel

Abstract excerpt

RATIONALE: Continuous episodes of infection are a feature of lung diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Lung antigen-presenting dendritic cells (DCs) sample inhaled antigen to initiate immune responses. Therefore, we hypothesized that inflammatory mediators, such as neutrophil elastase (NE) released into the lung, may be able to modulate their activity. OBJECTIVE:...

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PMID: 16959917
DOI: 10.1164/rccm.200605-632OC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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