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Article

Safety and Efficacy of Recombinant Alpha1-Antitrypsin Therapy in Cystic Fibrosis

21 Dec 2005

Abstract excerpt

Neutrophil elastase (NE) is thought to be the most important protease which damages the cystic fibrosis (CF) lung. Attempts have been made to suppress this activity using the plasma-derived inhibitor, alpha(1)-antitrypsin (AAT). In this pilot study, the safety and efficacy of inhaled recombinant human AAT (rAAT) as a treatment for CF were investigated. Thirty-nine patients participated in a prospective,...

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PMID: 16372352
DOI: 10.1002/ppul.20345

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