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Article

Elafin expression is regulated by CFTR-mutation and TGFβ1 in human bronchial epithelial cells.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Nov 2025

Thomassen Jan Christoph, Vohlen Christina, Rietschel Ernst, Alcazar Miguel A Alejandre, van Koningsbruggen-Rietschel Silke

Abstract excerpt

BACKGROUND: Cystic Fibrosis (CF) lung disease is characterized by inflammation and progressive matrix remodeling. These processes are influenced by genetic modifiers such as Transforming Growth Factor β1, (TGFβ1) which is enhanced by an imbalance of proteases, e.g. neutrophile elastase (NE) and its inhibitor elafin. Elevated TGFβ1 concentrations in sputum are linked to impaired lung function in people with CF...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40947321
DOI: 10.1016/j.jcf.2025.08.016

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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