Article

Alpha-1 Antitrypsin Limits Neutrophil Extracellular Trap Disruption of Airway Epithelial Barrier Function

2022-03-19

Abstract excerpt

Neutrophil extracellular traps contribute to lung injury in cystic fibrosis and asthma, but the mechanisms are poorly understood. We sought to understand the impact of human NETs on barrier function in primary human bronchial epithelial and a human airway epithelial cell line. We demonstrate that NETs disrupt airway epithelial barrier function by decreasing transepithelial electrical resistance and increasing para...

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Literature Corpus work: 4bfd545c-6ab0-5d47-834f-4491b883f2e3
DOI: 10.1101/2022.03.18.484920

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