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Article

MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons.

Stem cell reports - 8 Aug 2017

Beevers Joel E, Lai Mang Ching, Collins Emma, Booth Heather D E, Zambon Federico, Parkkinen Laura, Vowles Jane, Cowley Sally A, Wade-Martins Richard, Caffrey Tara M

Abstract excerpt

The H1 haplotype of the microtubule-associated protein tau (MAPT) locus is genetically associated with neurodegenerative diseases, including Parkinson's disease (PD), and affects gene expression and splicing. However, the functional impact on neurons of such expression differences has yet to be fully elucidated. Here, we employ extended maturation phases during differentiation of induced pluripotent stem cells...

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Source

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Identifiers

PMID: 28689993
DOI: 10.1016/j.stemcr.2017.06.005
PMCID: PMC5549835

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons.PMID 28689993Read ↗

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