Article
Increased genetic risk for obesity in premature coronary artery disease.
European journal of human genetics : EJHG - 1 Apr 2016
Cole Christopher B, Nikpay Majid, Stewart Alexandre F R, McPherson Ruth
Abstract excerpt
There is ongoing controversy as to whether obesity confers risk for CAD independently of associated risk factors including diabetes mellitus. We have carried out a Mendelian randomization study using a genetic risk score (GRS) for body mass index (BMI) based on 35 risk alleles to investigate this question in a population of 5831 early onset CAD cases without diabetes mellitus and 3832 elderly healthy control...
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