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Article

Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease.

American heart journal - 1 Aug 2010

Anderson Jeffrey L, Horne Benjamin D, Camp Nicola J, Muhlestein Joseph B, Hopkins Paul N, Cannon-Albright Lisa A, Mower Chrissa P, Park James J, Clarke Jessica L, Nicholas Zachary P, McKinney Jason T, Carlquist John F

Abstract excerpt

OBJECTIVE: The aim of this study is to discover common variants in 6 lipid metabolic genes and construct and validate a genetic risk score (GRS) based on the joint effects of genetic variants in multiple genes from lipid and other pathobiologic pathways. BACKGROUND: Explaining the genetic basis of coronary artery disease (CAD) is incomplete. Discovery and aggregation of genetic variants from multiple pathways may...

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Identifiers

PMID: 20691829
DOI: 10.1016/j.ahj.2010.05.031
PMCID: PMC2919893

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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